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p107 Rabbit Polyclonal Antibody

CAT: 0992-HA500481Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500481Size:100 µL
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Description
The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Product Name Alternative
107 kDa retinoblastoma-associated protein antibody Cellular protein 107 antibody Cellular protein p107 antibody CP107 antibody MGC40006 antibody p107 antibody PRB1 antibody RBL1 antibody RBL1_HUMAN antibody Retinoblastoma like protein 1 antibody retinoblastoma-like 1 (p107) antibody Retinoblastoma-like protein 1 antibody
Abbreviation
RBL1
Swiss Prot
P28749 Human
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human p107 aa 869-1,068 / 1,068.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
Raji cell lysates, human colon carcinoma tissue, human placenta tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:100-1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
121 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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