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TRIM33 Rabbit Polyclonal Antibody

CAT: 0992-HA500475Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500475Size:100 µL
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Description
The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade). This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
CAS Number
9007-83-4
Product Name Alternative
8030451N04Rik antibody AI413936 antibody cb1085 antibody DKFZp586K1123 antibody E3 ubiquitin-protein ligase TRIM33 antibody EC 6.3.2.- antibody Ectodermin antibody Ectodermin homolog antibody FLJ11429 antibody FLJ32925 antibody id:ibd2175 antibody MGC136680 antibody mKIAA1113 antibody OTTHUMP00000013662 antibody OTTHUMP00000013663 antibody Protein Rfg7 antibody PTC7 antibody Ret fused gene 7 antibody RET-fused gene 7 protein antibody RFG7 antibody Rfg7 protein antibody TF1G antibody TIF1 gamma antibody TIF1-gamma antibody TIF1G antibody TIF1GAMMA antibody TIFGAMMA antibody Transcription intermediary factor 1-gamma antibody Transcriptional intermediary factor 1 gamma antibody TRI33_HUMAN antibody trim33 antibody Tripartite motif containing 33 antibody Tripartite motif containing 33 protein antibody tripartite motif-containing 33 antibody Tripartite motif-containing protein 33 antibody wu:fc17f10 antibody zgc:136680 antibody
Abbreviation
TRIM33
Swiss Prot
Q9UPN9 Human, Q99PP7 Mouse
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant protein within human TRIM33 aa 900-1127 / 1127.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
K562 cell lysates, mouse uterus tissue lysates, human placenta tissue, human thyroid tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
123 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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