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PIAS4 Rabbit Polyclonal Antibody

CAT: 0992-HA500411Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500411Size:100 µL
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Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Binds to AT-rich DNA sequences, known as matrix or scaffold attachment regions (MARs/SARs). Catalyzes conjugation of SUMO2 to KAT5 in response to DNA damage, facilitating repair of DNA double-strand breaks (DSBs) via homologous recombination (HR). Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes.
CAS Number
9007-83-4
Product Name Alternative
E3 SUMO protein ligase PIAS4 antibody E3 SUMO-protein ligase PIAS4 antibody FLJ12419 antibody MGC35296 antibody PAIASgamma antibody PIAS 4 antibody PIAS gamma antibody PIAS-gamma antibody Pias4 antibody PIAS4_HUMAN antibody PIASG antibody PIASgamma antibody PIASy antibody Protein inhibitor of activated STAT 4 antibody Protein inhibitor of activated STAT protein 4 antibody Protein inhibitor of activated STAT protein gamma antibody Protein inhibitor of activated STAT protein PIASy antibody Zinc finger MIZ type containing 6 antibody ZMIZ 6 antibody ZMIZ6 antibody
Abbreviation
E3 SUMO-protein ligase PIAS4 PIASy Protein inhibitor of activated STAT protein 4 Protein inhibitor of activated STAT protein gamma (PIAS-gamma) PIAS4 PIASG
Swiss Prot
Q8N2W9 Human, Q3UGQ2 Mouse
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within human PIAS4 180-250.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
Mouse testis tissue lysate, rat kidney tissue lysate, human kidney tissue.
Concentration
1.83 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:600
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 56.5 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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