ELKS Rabbit Polyclonal Antibody

• Description:

  ELKS/RAB6-interacting/CAST family member 1 is a protein that in humans is encoded by the ERC1 gene. The name ELKS is derived from "protein rich in the amino acids E, L, K and S". The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t (10;12) (q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene. ELKS has been reported to direct vesicles with RAB6A to melanosomes. Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.

• Product Name Alternative:

  Cast 2 antibody CAST2 antibody CAZ associated structural protein 2 antibody Elks antibody ELKS/RAB6 interacting/CAST family member 1 antibody ELKS/RAB6-interacting/CAST family member 1 antibody ERC 1 antibody ERC protein 1 antibody ERC-1 antibody Erc1 antibody ERC1 protein antibody KIAA1081 antibody MGC12974 antibody RAB6 interacting protein 2 antibody RAB6-interacting protein 2 antibody RAB6IP2 antibody RB6I2_HUMAN antibody

• Abbreviation:

  ELKS/Rab6-interacting/CAST family member 1 ERC-1 Rab6-interacting protein 2 ERC1 ELKS KIAA1081 RAB6IP2

• Swiss Prot:

  Q8IUD2 Human, Q99MI1 Mouse, Q811U3 Rat

• Cellular Locus:

  Cytoplasm, cytoskeleton, microtubule organizing center, centrosomem, Cytoplasm, Membrane, Golgi apparatus membrane, Cell junction, synapse, presynaptic cell membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within human ELKS aa 850-1,116.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IHC-P, IF-Cell

• Positive Control:

  Hela cell lysate, 293 cell lysate, NIH/3T3 cell lysate, rat testis tissue, human liver tissue, human kidney tissue, human placenta tissue, mouse large intestine tissue, A375, SiHa.

• Concentration:

  2.39 mg/mL

• Dilution:

  WB: 1:500;IHC-P: 1:800;IF-Cell: 1:200

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 128 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4