NINJ1/Ninjurin-1 Rabbit Polyclonal Antibody

NINJ1/Ninjurin-1 Rabbit Polyclonal Antibody

• Description: Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis. Promotes cell adhesion by mediating homophilic interactions via its extracellular N-terminal adhesion motif (N-NAM). Involved in the progression of the inflammatory stress by promoting cell-to-cell interactions between immune cells and endothelial cells. Involved in leukocyte migration during inflammation by promoting transendothelial migration of macrophages via homotypic binding. Promotes the migration of monocytes across the brain endothelium to central nervous system inflammatory lesions. Acts as a regulator of Toll-like receptor 4 (TLR4) signaling triggered by lipopolysaccharide (LPS) during systemic inflammation; directly binds LPS. Acts as a mediator of both programmed and necrotic cell death. Plays a key role in the induction of plasma membrane rupture during programmed and necrotic cell death: oligomerizes in response to death stimuli to mediate plasma membrane rupture (cytolysis), leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response. Plays a role in nerve regeneration by promoting maturation of Schwann cells. Acts as a regulator of angiogenesis. Promotes the formation of new vessels by mediating the interaction between capillary pericyte cells and endothelial cells. Promotes osteoclasts development by enhancing the survival of prefusion osteoclasts. Also involved in striated muscle growth and differentiation.
• Product Name Alternative: Nerve injury induced protein 1 antibody Nerve injury-induced protein 1 antibody NIN1 antibody NINJ1 antibody NINJ1_HUMAN antibody NINJURIN antibody Ninjurin-1 antibody
• Abbreviation: Ninjurin-1 Nerve injury-induced protein 1 Secreted ninjurin-1 Soluble ninjurin-1 NINJ1
• CAS Number: 9007-83-4
• Swiss Prot: Q92982 Human
• Cellular Locus: Cell membrane, Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic peptide within human Ninjurin-1 aa 1 – 80 (Extracellular).
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB
• Positive Control: Human liver tissue lysate, RAW264.7 cell lysate, mouse kidney tissue lysate, mouse liver tissue lysate, human lung tissue lysate, A549 cell lysate, LNCAP cell lysate.
• Concentration: 2.3 mg/mL
• Dilution: WB: 1:1,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 16 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No