Scramblase 1 Rabbit Polyclonal Antibody

Scramblase 1 Rabbit Polyclonal Antibody

• Description: Scramblase is a protein responsible for the translocation of phospholipids between the two monolayers of a lipid bilayer of a cell membrane. In humans, phospholipid scramblases (PLSCRs) constitute a family of five homologous proteins that are named as hPLSCR1–hPLSCR5. Phospholipid scramblase 1 (PLSCR1), a lipid-binding protein that enters the nucleus via the nonclassical NLS (257)GKISKHWTGI (266). The structure of the nuclear localisation sequence of scramblase PLSCR1 complexed to importin was determined using X-ray diffraction with a resolution of 2.20 Ångströms. It is found in most mammals including humans. The import sequence lacks a continuous stretch of positively charged residues, and it is enriched in hydrophobic residues. Thus, Scramblase can transport negatively charged phospholipids from the inside of the cell to the outside of the cell. The importin structure is composed of many alpha helices that integrate the protein into membranes. The role of importin is to move proteins such as scramblase into the nucleus.
• Product Name Alternative: Ca (2+) dependent phospholipid scramblase 1 antibody Ca (2+)-dependent phospholipid scramblase 1 antibody Erythrocyte phospholipid scramblase antibody MM1 cell-derived transplantability-associated gene 1b, mouse, homolog of antibody MmTRA1a antibody MmTRA1b antibody Nor1 antibody Phospholipid scramblase 1 antibody PL scramblase 1 antibody PLS1_HUMAN antibody PLSCR 1 antibody Plscr1 antibody Scramblase1 antibody Tra1 antibody Tra1a antibody Tra1b antibody Transplantability-associated protein 1 antibody Tras1 antibody Tras2 antibody
• Abbreviation: PLSCR1
• CAS Number: 9007-83-4
• Swiss Prot: O15162 Human
• Cellular Locus: Cell membrane, Nucleus, Membrane, Cytoplasm, perinuclear region.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within N-terminal human Scramblase 1.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC, IP
• Positive Control: SK-MEL-28 cell lysate, HeLa cell lysate, THP-1 cell lysate, MDA-MB-231 cell lysate, HUVEC, human tonsil tissue, SK-MEL-28.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:50-1:100 ;IHC-P: 1:50-1:200 ;FC: 1:1,000 ;IP: 1-2μg/sample
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 35 kDa.
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No