USP8 Rabbit Polyclonal Antibody

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation.

9007-83-4

Deubiquitinating enzyme 8 antibody FLJ34456 antibody hUBPy antibody HumORF8 antibody KIAA0055 antibody MGC129718 antibody SPG59 antibody Ubiquitin carboxyl-terminal hydrolase 8 antibody Ubiquitin isopeptidase Y antibody ubiquitin specific peptidase 8 antibody Ubiquitin thioesterase 8 antibody Ubiquitin-specific-processing protease 8 antibody UBP8_HUMAN antibody UBPY antibody Usp8 antibody

Ubiquitin carboxyl-terminal hydrolase 8 Deubiquitinating enzyme 8 Ubiquitin isopeptidase Y hUBPy Ubiquitin thioesterase 8 Ubiquitin-specific-processing protease 8 KIAA0055

P40818 Human, Q80U87 Mouse,

Cytoplasm, Cell membrane, Nucleus.

Recombinant protein within human USP8 aa 1-250.

Non-conjugated

Rabbit polyclonal Antibody

WB, IHC-P

A375 cell lysate, A431 cell lysate, HepG2 cell lysate, 293T cell lysate, MCF-7 cell lysate, mouse testis tissue lysate, SK-Br-3 cell lysate, F9 cell lysate, rat lung tissue lysate, Hela cell lysate, mouse kidney tissue, human colon carcinoma tissue.

2.3 mg/mL

WB: 1:1,000 ;IHC-P: 1:1,000

Immunogen affinity purified.

Liquid

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 128 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.