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USP28 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-52Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-52Size:100 µL
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Description
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF (FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells.
CAS Number
9007-83-4
Product Name Alternative
Deubiquitinating enzyme 28 antibody KIAA1515 antibody Ubiquitin carboxyl terminal hydrolase 28 antibody Ubiquitin carboxyl-terminal hydrolase 28 antibody ubiquitin carboxyl-terminal hydrolase 28 variant 1 antibody Ubiquitin specific peptidase 28 antibody Ubiquitin specific processing protease 28 antibody Ubiquitin specific protease 28 antibody Ubiquitin thioesterase 28 antibody Ubiquitin thiolesterase 28 antibody Ubiquitin-specific-processing protease 28 antibody UBP28_HUMAN antibody USP 28 antibody USP28 antibody USP28 protein antibody
Abbreviation
USP28, KIAA1515
Swiss Prot
Q96RU2 Human
Cellular Locus
Nucleus, nucleoplasm.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human USP28 aa 550-700.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, FC
Positive Control
K562, A549, Daudi, MG-63.
Concentration
1 mg/mL
Dilution
WB: 1:200-1:1,000 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 122 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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