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PP-X Rabbit Polyclonal Antibody

CAT: 0992-HA500276Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500276Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
CAS Number
9007-83-4
Product Name Alternative
PP X antibody PP-X antibody Pp4 antibody PP4C antibody PP4C_HUMAN antibody PPH3 antibody PPP4 antibody ppp4c antibody PPX antibody protein phosphatase 4 (formerly X), catalytic subunit antibody Protein phosphatase 4 catalytic subunit antibody Protein phosphatase X antibody protein phosphatase X, catalytic subunit antibody Serine/threonine protein phosphatase 4 catalytic subunit antibody Serine/threonine-protein phosphatase 4 catalytic subunit antibody
Abbreviation
PPP4C
Swiss Prot
P60510 Human
Cellular Locus
Centrosome, Nucleus, Cytoplasm.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human PP-X aa 151-307 / 307.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
293T cell lysates, human colon tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:100-1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
35 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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