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IL-10RA Rabbit Polyclonal Antibody

CAT: 0992-HA500251Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500251Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.
CAS Number
9007-83-4
Product Name Alternative
CD210 antibody CDw210a antibody CDw210a antigen antibody HIL 10R antibody HIL10R antibody I10R1_HUMAN antibody IL 10R 1 antibody IL 10R A antibody IL 10R antibody IL 10R1 antibody IL-10 receptor subunit alpha antibody IL-10R subunit 1 antibody IL-10R subunit alpha antibody IL-10R1 antibody IL-10RA antibody IL10R antibody IL10R1 antibody IL10RA antibody Interleukin 10 receptor alpha antibody Interleukin 10 receptor alpha chain antibody Interleukin-10 receptor subunit 1 antibody Interleukin-10 receptor subunit alpha antibody
Abbreviation
IL10RA
Swiss Prot
Q13651 Human
Cellular Locus
Cytoplasm, Cell membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within human IL-10RA aa 491-540/578.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
Daudi cell lysates, Jurkat cell lysate, THP-1 cell lysate, MCF-7 cell lysate, human tonsil tissue, SiHa.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IHC-P: 1:200-1:1,000;IF-Cell: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
63 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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