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IL-17A Rabbit Polyclonal Antibody

CAT: 0992-ER1902-37Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1902-37Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Interleukin 17A (IL-17 or IL-17A) is a pro-inflammatory cytokine. This cytokine is produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23. Originally, Th17 was identified in 1993 by Rouvier et al. who isolated IL17 transcript from a rodent T-cell hybridoma. The protein encoded by IL17A is a founding member of IL-17 family (see below). IL17 protein exhibits a high homology with a viral IL-17-like protein encoded in the genome of T-lymphotropic rhadinovirus Herpesvirus saimiri.[2] In rodents, IL-17 is often referred to as CTLA8.The biologically active IL-17 interacts with type I cell surface receptor IL-17R. In turn, there are at least three variants of IL-17R referred to as IL17RA, IL17RB, and IL17RC. After binding to the receptor, IL-17 activates several signalling cascades that, in turn, lead to the induction of chemokines. Acting as chemoattractants, these chemokines recruit the immune cells, such as monocytes and neutrophils to the site of inflammation. Typically, the signaling events mentioned above follow an invasion of the body by pathogens. Promoting the inflammation, IL-17 acts in concert with tumor necrosis factor and interleukin-1.Moreover, an activation of IL-17 signalling is often observed in the pathogenesis of various autoimmune disorders, such as psoriasis.
CAS Number
9007-83-4
Product Name Alternative
CTLA 8 antibody CTLA-8 antibody CTLA8 antibody Cytotoxic T lymphocyte associated antigen 8 antibody Cytotoxic T lymphocyte associated protein 8 antibody Cytotoxic T lymphocyte associated serine esterase 8 antibody Cytotoxic T-lymphocyte-associated antigen 8 antibody IL 17A antibody IL-17 antibody IL-17A antibody IL17 antibody IL17_HUMAN antibody Il17a antibody Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody Interleukin 17A antibody Interleukin-17A antibody Interleukin17 antibody Interleukin17A antibody OTTHUMP00000016597 antibody OTTMUSP00000046003 antibody
Abbreviation
Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,IL17A
Swiss Prot
Q16552 Human, Q62386 Mouse
Cellular Locus
Secreted.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human IL17 aa 1-155 / 155.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Recombinant protein lysates, Rat stomach tissue lysates, Human skeletal muscle tissue lysate, human fetal skeletal muscle tissue, human esophagus tissue, mouse colon tissue, Jurkat.
Concentration
1 mg/mL
Dilution
WB: 1:500 ;IHC-P: 1:50-1:800 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 18 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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