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IL-17 Rabbit Polyclonal Antibody

CAT: 0992-ER1706-91Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1706-91Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cytokines are small, soluble proteins with pleiotropic effects on a variety of cell types. Cytokines have a regulatory function over the immune system and mediate aspects of inflammatory response. They exert their biological effects through the binding of membrane-bound receptors which, in turn, initiate signal transduction cascades and elicit physiological changes in their target cell. Interleukin-17 (IL-17) and its cognate receptor, IL-17R, are an example of such a cytokine receptor pair. Originally identified as a rodent cDNA termed CTLA8, IL-17 is capable of inducing the secretion of IL-6 and IL-8 and augmenting the expression of ICAM-1 in human fibroblast cultures. The IL-17 protein exhibits a striking degree of homology with the HSV13 protein which mimics its function. The IL-17 receptor is a type I transmembrane protein 864 amino acids in length, that is highly expressed in spleen and kidney.
CAS Number
9007-83-4
Product Name Alternative
CTLA 8 antibody CTLA-8 antibody CTLA8 antibody Cytotoxic T lymphocyte associated antigen 8 antibody Cytotoxic T lymphocyte associated protein 8 antibody Cytotoxic T lymphocyte associated serine esterase 8 antibody Cytotoxic T-lymphocyte-associated antigen 8 antibody IL 17A antibody IL-17 antibody IL-17A antibody IL17 antibody IL17_HUMAN antibody Il17a antibody Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody Interleukin 17A antibody Interleukin-17A antibody Interleukin17 antibody Interleukin17A antibody OTTHUMP00000016597 antibody OTTMUSP00000046003 antibody
Abbreviation
IL-17, IL-17A, CTLA-8, IL17A, CTLA8, IL17
Swiss Prot
Q16552 Human, Q61453 Rat
Cellular Locus
Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human IL-17 aa 60-109 / 155.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Human tonsil tissue, Jurkat.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2000 ;IHC-P: 1:1,000 ;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 18 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No