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Unrip Rabbit Polyclonal Antibody

CAT: 0992-HA500221Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500221Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
CAS Number
9007-83-4
Product Name Alternative
MAP activator with WD repeats antibody MAWD antibody PTWD antibody Serine-threonine kinase receptor-associated protein antibody serine/threonine kinase receptor associated protein antibody strap antibody STRAP_HUMAN antibody UNR-interacting protein antibody UNRIP antibody WD 40 repeat protein PT WD antibody WD-40 repeat protein PT-WD antibody
Abbreviation
STRAP
Swiss Prot
Q9Y3F4 Human, Q9Z1Z2 Mouse, Q5XIG8 Rat
Cellular Locus
Nucleus, Cytoplasm.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within C-terminal human Unrip from aa 200-350.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell, FC
Positive Control
HepG2 cell lysate, Hela cell lysate, mouse brain tissue lysate, mouse cerebellum tissue lysate, A431 cell lysate, rat brain tissue lysate, human placenta tissue, mouse colon tissue, SH-SY5Y, Hela.
Concentration
1 mg/mL
Dilution
WB: 1:1,000-1:5,000;IHC-P: 1:50-1:500;IF-Cell: 1:50-1:100;FC: 1:500-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
38 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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