MST1 Rabbit Polyclonal Antibody

• Description:

  Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

• Product Name Alternative:

  Kinase responsive to stress antibody Krs2 antibody Mammalian STE20 like protein kinase 1 antibody Mammalian STE20-like protein kinase 1 antibody Mammalian sterile 20 like 1 antibody MST-1 antibody MST1 antibody Serine/threonine kinase 4 antibody Serine/threonine protein kinase Krs 2 antibody Serine/threonine-protein kinase 4 antibody Serine/threonine-protein kinase Krs-2 antibody STE20 like kinase MST1 antibody STE20-like kinase MST1 antibody STK4 antibody STK4_HUMAN antibody TIIAC antibody YSK3 antibody

• Abbreviation:

  Serine/threonine-protein kinase 4 Mammalian STE20-like protein kinase 1 MST-1 STE20-like kinase MST1 Serine/threonine-protein kinase Krs-2 Serine/threonine-protein kinase 4 37kDa subunit MST1/N Serine/threonine-protein kinase 4 18kDa subunit MST1/C

• Swiss Prot:

  Q13043 Human, Q9JI11 Mouse

• Cellular Locus:

  Cytoplasm, Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide within human MST1 aa 1-50.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IHC-P

• Positive Control:

  HepG2 cell lysate, THP-1 cell lysate, rat kidney tissue, human spleen tissue, human placenta tissue, mouse testis tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:1,000-1:5,000;IHC-P: 1:100-1:500

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 56 kDa.

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4