HLA-DRB4 Recombinant Rabbit Monoclonal Antibody [JE55-85]

HLA-DRB4 Recombinant Rabbit Monoclonal Antibody [JE55-85]

• Description: Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II α/β dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (β-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
• Product Name Alternative: DR 4 antibody DR beta 4 chain antibody DR4 antibody DRB1 transplantation antigen antibody DRB4 antibody DRB4_HUMAN antibody HLA class II histocompatibility antigen antibody HLA class II histocompatibility antigen DR beta 4 chain antibody HLA-DRB4 antibody Human leucocyte antigen DRB4 antibody Leukocyte antigen antibody Major histocompatibility complex class II DR beta 4 antibody MHC class II antigen DRB4 antibody MHC class II antigen HLA DR beta antibody MHC class2 antigen antibody MHC HLA DR-beta chain antibody
• Abbreviation: HLA-DRB4
• CAS Number: 9000-83-3
• Swiss Prot: P13762 Human
• Cellular Locus: Lysosome membrane, Endosome membrane, Late endosome membrane, trans-Golgi network membrane, Endoplasmic reticulum membrane, Cell membrane.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide corresponding to the extracellular domain of Human HLA-DRB4.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, FC
• Positive Control: Raji cell lysates, human tonsil tissue, human spleen tissue, human breast carcinoma tissue, Jurkat.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 30 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes