COPS3/CSN3 Recombinant Rabbit Monoclonal Antibody [JE47-48]

COPS3/CSN3 Recombinant Rabbit Monoclonal Antibody [JE47-48]

• Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
• Product Name Alternative: Constitutive photomorphogenic homolog subunit 3 antibody COP 9 (constitutive photomorphogenic) subunit 3 antibody COP 9 complex homolog subunit 3 antibody COP 9 complex S3 antibody COP 9 complex subunit 3 antibody COP 9 constitutive photomorphogenic homolog subunit 3 antibody COP 9 homolog antibody COP 9 signalosome complex subunit 3 antibody COP 9 signalosome subunit 3 antibody COP 9 subunit 3 antibody COP9 (constitutive photomorphogenic) subunit 3 antibody COP9 complex homolog subunit 3 antibody COP9 complex S3 antibody COP9 complex subunit 3 antibody COP9 constitutive photomorphogenic homolog subunit 3 antibody COP9 homolog antibody COP9 signalosome complex subunit 3 antibody COP9 signalosome subunit 3 antibody COP9 subunit 3 antibody COPS 3 antibody cops3 antibody CSN 3 antibody CSN3 antibody CSN3_HUMAN antibody JAB 1 containing signalosome subunit 3 antibody JAB1 containing signalosome subunit 3 antibody JAB1-containing signalosome subunit 3 antibody SGN 3 antibody SGN3 antibody Signalosome subunit 3 antibody
• Abbreviation: SGN3, Signalosome subunit 3, COPS3, CSN3
• CAS Number: 9000-83-3
• Swiss Prot: Q9UNS2 Human, O88543 Mouse, Q68FW9 Rat
• Cellular Locus: Cytoplasm. Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human COPS3 / CSN3 aa 280-423 / 423.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: Human skeletal muscle tissue, Rat bone marrow, A431, HCT116, rat heart tissue, human liver cancer tissue, human breast tissue, human pancreas tissue, mouse kidney tissue, mouse heart tissue, 293.
• Concentration: 1 mg/mL
• Dilution: WB:1:500-1:1,000;IF-Cell:1:500-1:2,000;IHC-P:1:50-1:200;FC:1:50-1:100
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 48 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes