HIF-2 alpha Recombinant Rabbit Monoclonal Antibody [JB24-42]

• Description:

  Endothelial PAS domain-containing protein 1 (EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2α)) is a protein that is encoded by the EPAS1 gene in mammals. It is a type of hypoxia-inducible factor, a group of transcription factors involved in the physiological response to oxygen concentration. The gene is active under hypoxic conditions. It is also important in the development of the heart, and for maintaining the catecholamine balance required for protection of the heart. Mutation often leads to neuroendocrine tumors. The EPAS1 gene encodes one subunit of a transcription factor involved in the induction of genes regulated by oxygen, and which is induced as oxygen concentration falls (hypoxia). The protein contains a basic helix-loop-helix protein dimerization domain as well as a domain found in signal transduction proteins which respond to oxygen levels. EPAS1 is involved in the development of the embryonic heart and is expressed in endothelial cells that line the walls of blood vessels in the umbilical cord. EPAS1 is also essential for the maintenance of catecholamine homeostasis and protection against heart failure during early embryonic development. Catecholamines regulated by EPAS1 include epinephrine and norepinephrine. It is critical that the production of catecholamines remain in homeostatic conditions so that both the delicate fetal heart and the adult heart do not overexert themselves and induce heart failure. Catecholamine production in the embryo is related to control of cardiac output by increasing the fetal heart rate.

• Product Name Alternative:

  Basic helix loop helix PAS protein MOP2 antibody Basic-helix-loop-helix-PAS protein MOP2 antibody bHLHe73 antibody Class E basic helix-loop-helix protein 73 antibody ECYT4 antibody Endothelial PAS domain containing protein 1 antibody Endothelial pas domain protein 1 antibody Endothelial PAS domain-containing protein 1 antibody EPAS 1 antibody EPAS-1 antibody EPAS1 antibody EPAS1_HUMAN antibody HIF 1 alpha like factor antibody HIF 2 alpha antibody HIF-1-alpha-like factor antibody HIF-2-alpha antibody HIF2-alpha antibody HIF2A antibody HLF antibody Hypoxia inducible factor 2 alpha antibody Hypoxia inducible factor 2 alpha subunit antibody Hypoxia-inducible factor 2-alpha antibody Member of PAS protein 2 antibody Member of pas superfamily 2 antibody MOP 2 antibody MOP2 antibody PAS domain-containing protein 2 antibody PASD2 antibody

• Abbreviation:

  EPAS-1, bHLHe73, HLF, HIF-2-alpha, HIF2-alpha, EPAS1, BHLHE73, HIF2A, MOP2, PASD2

• Swiss Prot:

  Q99814 Human, P97481 Mouse, Q9JHS1 Rat

• Cellular Locus:

  Nucleus, Nucleus speckle.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide within Human HIF-2 alpha aa 61-110 / 870.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IHC-P, FC

• Positive Control:

  Mouse lung tissue lysate, Siha cell lysate, rat lung tissue, human breast tissue, human placenta tissue, mouse colon tissue, HUVEC.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500-1:2,000 ;IHC-P: 1:50-1:1,000 ;FC: 1:50-1:100

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 96 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3