AMPK alpha 1/2 Recombinant Rabbit Monoclonal Antibody [PSH08-86]

AMPK alpha 1/2 Recombinant Rabbit Monoclonal Antibody [PSH08-86]

• Description: 5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene. The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. 5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene. The protein encoded by this gene belongs to the serine/threonine protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. A recent study proposes a role in the metastatic cascade and phenotype determination of pancreatic cancer.
• Product Name Alternative: 5 AMP activated protein kinase alpha 1catalytic subunit antibody 5 AMP activated protein kinase catalytic alpha 1 chain antibody 5' AMP activated protein kinase catalytic subunit alpha 1 antibody 5'-AMP-activated protein kinase catalytic subunit alpha-1 antibody AAPK1 antibody AAPK1_HUMAN antibody ACACA kinase antibody acetyl CoA carboxylase kinase antibody AI194361 antibody AI450832 antibody AL024255 antibody AMP -activate kinase alpha 1 subunit antibody AMP-activate kinase alpha 1 subunit antibody AMP-activated protein kinase, catalytic, alpha -1 antibody AMPK 1 antibody AMPK alpha 1 antibody AMPK alpha 1 chain antibody AMPK antibody AMPK subunit alpha 1 antibody AMPK subunit alpha-1 antibody AMPK1 antibody AMPKa1 antibody AMPKalpha1 antibody C130083N04Rik antibody cb116 antibody EC 2.7.11.1 antibody HMG CoA reductase kinase antibody HMGCR kinase antibody hormone sensitive lipase kinase antibody Hydroxymethylglutaryl CoA reductase kinase antibody im:7154392 antibody kinase AMPK alpha1 antibody MGC33776 antibody MGC57364 antibody OTTHUMP00000161795 antibody OTTHUMP00000161796 antibody PRKAA 1 antibody PRKAA1 antibody Protein kinase AMP activated alpha 1 catalytic subunit antibody SNF1-like protein AMPK antibody SNF1A antibody Tau protein kinase PRKAA1 antibody wu:fa94c10 antibody 5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody AAPK2_HUMAN antibody Acetyl-CoA carboxylase kinase antibody AMPK alpha 2 chain antibody AMPK subunit alpha-2 antibody AMPK2 antibody AMPKa2 antibody AMPKalpha2 antibody Hydroxymethylglutaryl-CoA reductase kinase antibody PRKAA antibody PRKAA2 antibody Protein kinase AMP activated alpha 2 catalytic subunit antibody Protein kinase AMP activated catalytic subunit alpha 2 antibody
• Abbreviation: PRKAA1, AMPK1, PRKAA2, AMPK, AMPK2
• CAS Number: 9000-83-3
• Swiss Prot: Q13131 Human, P54646 Human, Q5EG47 Mouse, Q8BRK8 Mouse, P54645 Rat, Q09137 Rat
• Cellular Locus: Cytoplasm, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human AMPK alpha 2 aa 1-400.
• Isotype: IgG
• Clone: PSH08-86
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: HepG2 cell lysate, HeLa cell lysate, RAW264.7 cell lysate, C6 cell lysate, mouse brain tissue, mouse heart tissue, rat brain tissue, rat heart tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IHC-P: 1:200-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 64/62 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes