LOX Recombinant Rabbit Monoclonal Antibody [JU30-23]

LOX Recombinant Rabbit Monoclonal Antibody [JU30-23]

• Description: The lysyl oxidase family of extracellular proteins includes LOX and four LOX-like enzymes, which are responsible for the deamination of peptidyl lysine residues of collagens and elastin. They also catalyze inter- and intra-crosslinking reactions. Overexpression of LOX may cause severe fibrotic degeneration due to its high resistance to degradative enzymes. Procollagen C-proteinase activity processes LOX from a precursor protein to a mature form. Activation of LOX occurs in normal developing and adult skin, and alterations in LOX expression and activity are associated with skin aging and senescence. LOX is crucial for development of the cardiovascular and respiratory systems. In addition, LOX plays a role in cancer, wound healing, as well as cell motility, chemotaxis and differentiation.
• Product Name Alternative: lox antibody LYOX antibody LYOX_HUMAN antibody Lysyl oxidase antibody MGC105112 antibody Protein lysine 6 oxidase antibody Protein-lysine 6-oxidase antibody
• Abbreviation: LOX
• CAS Number: 9000-83-3
• Swiss Prot: P28300 Human, P28301 Mouse, P16636 Rat
• Cellular Locus: Secreted, extracellular space.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat, Zebrafish
• Immunogen: Synthetic peptide within Human LOX aa 368-417 / 417.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC, IF-Tissue
• Positive Control: PC-3M cell lysate, Jurkat cell lysate, Mouse lung tissue lysate, Rat lung tissue lysate, Mouse brain tissue lysate, Rat brain tissue lysate, zebrafish tissue lysates, Jurkat, human stomach cancer tissue, human kidney tissue, mouse kidney tissue, rat kidney tissue, zebrafish tissue lysates.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:1,000 ;IHC-P: 1:200-1:1,000 ;FC: 1:1,000 ;IF-Tissue: 1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 47 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes