IRF7 Recombinant Rabbit Monoclonal Antibody [SC0617]

IRF7 Recombinant Rabbit Monoclonal Antibody [SC0617]

• Description: IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. The IRF7 pathway was shown to be silenced in some metastatic breast cancer cell lines, which may help the cells avoid the host immune response. Restoring IRF7 to these cell lines reduced metastases and increased host survival time in animal models. The IRF7 gene and product were shown to be defective in a patient with severe susceptibility to H1N1 influenza, while susceptibility to other viral diseases such as CMV, RSV, and parainfluenza was unaffected.
• Product Name Alternative: IMD39 antibody Interferon regulatory factor 7 antibody Interferon regulatory factor 7H antibody IRF 7 antibody IRF 7A antibody IRF 7H antibody IRF-7 antibody IRF7 antibody IRF7_HUMAN antibody IRF7A antibody IRF7B antibody IRF7C antibody IRF7H antibody
• Abbreviation: IRF-7, IRF7
• CAS Number: 9000-83-3
• Swiss Prot: Q92985 Human, P70434 Mouse
• Cellular Locus: Nucleus, Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat, Zebrafish
• Immunogen: Synthetic peptide within human IRF7 aa 200-240.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P, FC, IP
• Positive Control: Jurkat cell lysate, Raji cell lysate, hybrid fish (crucian-carp) brain tissue lysates, PC-12, HepG2, 293, human tonsil tissue, human spleen tissue, human kidney tissue, mouse liver tissue, mouse kidney tissue, mouse heart tissue, Raji.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000-1:5,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:50-1:200 ;FC: 1:100 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 54 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes