IKB epsilon Recombinant Rabbit Monoclonal Antibody [JM62-63]

IKB epsilon Recombinant Rabbit Monoclonal Antibody [JM62-63]

• Description: Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene. NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis. NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6), AP-1 (JUN), and NFAT (see NFATC1).
• Product Name Alternative: I kappa B epsilon antibody I-kappa-B-epsilon antibody IkappaBepsilon antibody IkB E antibody IkB-E antibody IkB-epsilon antibody IKBE antibody IKBE_HUMAN antibody MGC72568 antibody NF kappa B inhibitor epsilon antibody NF kappa BIE antibody NF-kappa-B inhibitor epsilon antibody NF-kappa-BIE antibody NFkappa BIE antibody NFkappaB inhibitor epsilon antibody NFKBIE antibody Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon antibody OTTHUMP00000016522 antibody Slc35b2 antibody solute carrier family 35, member B2 antibody
• Abbreviation: NF-kappa-BIE, IkB-E, IkB-epsilon, IkappaBepsilon
• CAS Number: 9000-83-3
• Swiss Prot: O00221 Human
• Cellular Locus: Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Synthetic peptide within Human IKB epsilon aa 175-224 / 500.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IP
• Positive Control: THP-1 cell lysate, Jurkat cell lysate, Hela cell lysate, human tonsil tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 53 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes