IP3 Receptor Recombinant Rabbit Monoclonal Antibody [JA11-35]

IP3 Receptor Recombinant Rabbit Monoclonal Antibody [JA11-35]

• Description: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
• Product Name Alternative: 4 antibody 5-trisphosphate receptor antibody 5-trisphosphate receptor type 1 antibody DKFZp313E1334 antibody DKFZp313N1434 antibody inositol 1 4 5 triphosphate receptor type 1 antibody Inositol 1 4 5 trisphosphate Receptor Type 1 antibody Inositol 1 antibody InsP3R1 antibody IP3 antibody IP3 receptor antibody IP3 receptor isoform 1 antibody IP3R 1 antibody IP3R antibody IP3R1 antibody ITPR 1 antibody Itpr1 antibody ITPR1_HUMAN antibody SCA15 antibody SCA16 antibody SCA29 antibody Type 1 inositol 1 4 5 trisphosphate receptor antibody Type 1 inositol 1 antibody Type 1 InsP3 receptor antibody
• Abbreviation: IP3R 1, InsP3R1, Type 1 InsP3 receptor, ITPR1, INSP3R1
• CAS Number: 9000-83-3
• Swiss Prot: Q14643 Human, P11881 Mouse, P29994 Rat
• Cellular Locus: Endoplasmic reticulum membrane, secretory vesicle membrane, perinuclear region.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human IP3 Receptor aa 2190-2280 / 2758.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IHC-Fr, IF-Tissue
• Positive Control: Rat brain tissue lysate, Mouse brain tissue lysate, human cerebellum tissue, mouse cerebellum tissue, rat cerebellum tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:1,000 ;IHC-Fr: 1:500 ;IF-Tissue: 1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 314 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes