Glucocorticoid Receptor Recombinant Rabbit Monoclonal Antibody [JF0952]
CAT:
992-ET1702-11
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
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Glucocorticoid Receptor Recombinant Rabbit Monoclonal Antibody [JF0952]
- Description: The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that mediates the effects of glucocorticoids. The most abundant isoform is GR α. GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis, cell growth and differentiation. A significant class of genes suppressed by GR is controlled by the transcription factor AP-1. GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids. It has been revealed that GR forms a complex with HSP 90, rendering the non-ligand bound receptor transcriptionally inactive. More importantly, mutant GRs lacking the signaling domain remain constitutively active.
- Product Name Alternative: GCCR antibody GCR antibody GCR_HUMAN antibody GCRST antibody glucocorticoid nuclear receptor variant 1 antibody Glucocorticoid receptor antibody GR antibody GRL antibody Grl1 antibody nr3c1 antibody Nuclear receptor subfamily 3 group C member 1 antibody nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) antibody
- Abbreviation: GR, NR3C1
- CAS Number: 9000-83-3
- Swiss Prot: P04150 Human, P06537 Mouse, P06536 Rat
- Cellular Locus: Cytoplasm, Nucleus, Mitochondrion.
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Immunogen: Recombinant protein within Human Glucocorticoid Receptor aa 2-220 / 777.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Recombinant Rabbit monoclonal Antibody
- Applications: WB, IF-Cell, FC
- Positive Control: HeLa cell lysate, A549 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, Zebrafish tissue lysate, C6, HeLa, hybrid fish (crucian-carp) heart tissue lysates.
- Concentration: 1 mg/mL
- Dilution: WB: 1:2,000 ;IF-Cell: 1:100 ;FC: 1:1,000
- Purity: Protein A affinity purified.
- Form: Liquid
- Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 86 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Recombinant Antibody: Yes