Integrin alpha 4 Recombinant Rabbit Monoclonal Antibody [JA09-36]

Integrin alpha 4 Recombinant Rabbit Monoclonal Antibody [JA09-36]

• Description: Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
• Product Name Alternative: 269C wild type antibody Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody CD49 antigen like family member D antibody CD49 antigen-like family member D antibody CD49d antibody IA4 antibody Integrin alpha 4 antibody Integrin alpha 4 subunit antibody Integrin alpha IV antibody Integrin alpha-4 antibody Integrin alpha-IV antibody Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA 4 receptor) antibody ITA4_HUMAN antibody ITGA4 antibody MGC90518 antibody OTTHUMP00000205320 antibody Very late activation protein 4 receptor, alpha 4 subunit antibody VLA 4 subunit alpha antibody VLA-4 subunit alpha antibody VLA4 antibody
• Abbreviation: ITGA4, CD49d
• CAS Number: 9000-83-3
• Swiss Prot: P13612 Human, Q00651 Mouse,
• Cellular Locus: Membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Integrin alpha 4 aa 983-1032 / 1032.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, FC
• Positive Control: Jurkat cell lysate, mouse spleen tissue lysate, rat spleen tissue lysate, RAW264.7 cell lysate, human tonsil tissue, human spleen tissue, Jurkat.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:50-1:200 ;FC: 1:10-1:50
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 115 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes