Perilipin A Recombinant Rabbit Monoclonal Antibody [JM10-96]

Perilipin A Recombinant Rabbit Monoclonal Antibody [JM10-96]

• Description: Perilipin is a protein that coats lipid droplets (LDs) in adipocytes, the fat-storing cells in adipose tissue. In fact, PLIN1 is greatly expressed in white adipocytes.It controls adipocyte lipid metabolism. It handles essential functions in the regulation of basal and hormonally stimulated lipolysis and also rises the formation of large LDs which implies an increase in the synthesis of triglycerides.In humans, Perilipin A is the most abundant protein associated with the adipocyte LDs and lower PLIN1 expression is related with higher rates of lipolysis.Under basal conditions, Perilipin acts as a protective coating of LDs from the body's natural lipases, such as hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), which break triglycerides into glycerol and free fatty acids for use in lipid metabolism.In times of energy deficit, Perilipin is hyperphosphorylated by PKA following β-adrenergic receptor activation. Phosphorylated perilipin changes conformation, exposing the stored lipids to hormone-sensitive lipase-mediated lipolysis.
• Product Name Alternative: Lipid droplet associated protein antibody Lipid droplet-associated protein antibody PERI antibody Perilipin A antibody Perilipin antibody Perilipin-1 antibody PerilipinA antibody PLIN antibody PLIN1 antibody PLIN1_HUMAN antibody Perilipin-1 antibody
• Abbreviation: PLIN1
• CAS Number: 9000-83-3
• Swiss Prot: O60240 Human, Q8CGN5 Mouse
• Cellular Locus: Endoplasmic reticulum, Lipid droplet.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic peptide within Human Perilipin A aa 470-510 / 522.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue
• Positive Control: Human liver tissue lysates, MCF-7, HepG2, Hela.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:100-1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 56 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes