Occludin Recombinant Rabbit Monoclonal Antibody [JJ091-08]

Occludin Recombinant Rabbit Monoclonal Antibody [JJ091-08]

• Description: Occludin is an integral membrane protein closely associated with the tight junctions of epithelial and endothelial cells. Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of occludin. Expression of occludin is up-regulated by poly-unsaturated fatty acids, increasing transendothelial cell resistance and reducing cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction.
• Product Name Alternative: BLCPMG antibody FLJ08163 antibody FLJ18079 antibody FLJ77961 antibody FLJ94056 antibody MGC34277 antibody Occludin antibody Ocln antibody OCLN_HUMAN antibody Tight junction protein occludin antibody
• Abbreviation: OCLN
• CAS Number: 9000-83-3
• Swiss Prot: Q16625 Human, Q61146 Mouse
• Cellular Locus: Cell membrane, tight junction.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic peptide within N-terminal human Occludin.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IP, FC, IF-Cell
• Positive Control: MCF-7 cell lysate, Mouse smooth muscle tissue lysate, Caco-2.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;FC: 1:1,000 ;IP: Use at an assay dependent concentration. ;IF-Cell: 1:500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 59 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes