Sumo 2+3 Recombinant Rabbit Monoclonal Antibody [JJ087-04]

Sumo 2+3 Recombinant Rabbit Monoclonal Antibody [JJ087-04]

• Description: The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2 and SUMO-3 proteins localize to the nuclear membrane, nuclear bodies and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IkBa, MDM2, p53, PML and Ran GAP1. SUMO-2 and SUMO-3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates b-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease.
• Product Name Alternative: HSMT3 antibody MGC117191 antibody OTTHUMP00000115275 antibody OTTHUMP00000115276 antibody OTTHUMP00000115277 antibody Sentrin 2 antibody Small ubiquitin like modifier 2 antibody Small ubiquitin related modifier 2 antibody small ubiquitin-like modifier 3 antibody small ubiquitin-related modifier 3 antibody SMT3 homolog 1 antibody SMT3 homolog 2 antibody SMT3 suppressor of mif two 3 homolog 1 antibody SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) antibody SMT3 suppressor of mif two 3 homolog 2 antibody SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) antibody SMT3 suppressor of mif two 3 homolog 3 antibody SMT3A antibody SMT3B antibody SMT3H1 antibody SMT3H2 antibody Sumo2 antibody Sumo3 antibody Ubiquitin like protein SMT3A antibody Ubiquitin like protein SMT3B antibody
• Abbreviation: SUMO-2, Smt3B, SUMO2, SUMO-3, Smt3A, SUMO3
• CAS Number: 9000-83-3
• Swiss Prot: P55854 Human, P61956 Human, P61957 Mouse, Q9Z172 Mouse, P61959 Rat, Q5XIF4 Rat
• Cellular Locus: Cytoplasm, Nucleus.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human Sumo 3 aa 11-60 / 103.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P
• Positive Control: HeLa cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, Human lung tissue lysate, Mouse kidney tissue lysate, HeLa, NIH/3T3, human kidney tissue, mouse kidney tissue, rat kidney tissue, mouse large intestine tissue, rat skin tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 12 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes