MLKL Recombinant Rabbit Monoclonal Antibody [SA40-04]

MLKL Recombinant Rabbit Monoclonal Antibody [SA40-04]

• Description: Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis.
• Product Name Alternative: 9130019I15Rik antibody FLJ34389 antibody hMLKL antibody Mixed lineage kinase domain like antibody Mixed lineage kinase domain like protein antibody Mixed lineage kinase domain-like protein antibody Mlkl antibody MLKL_HUMAN antibody
• Abbreviation: hMLKL
• CAS Number: 9000-83-3
• Swiss Prot: Q8NB16 Human, Q9D2Y4 Mouse
• Cellular Locus: Cytoplasm, Cell membrane, Golgi apparatus.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Recombinant protein within Human MLKL aa 333-471 / 471.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Cell, FC
• Positive Control: HUVEC cell lysate, HT-29 cell lysate, HeLa cell lysate, THP-1 cell lysate, U-937 cell lysate, K-562 cell lysate, NIH/3T3 cell lysate, HeLa, HT-29, human tonsil tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:5,000 ;IHC-P: 1:50-1:2000 ;IF-Cell: 1:100 ;FC: 1:1,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 54 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes