p70 S6 Kinase beta Rabbit Polyclonal Antibody

p70 S6 Kinase beta Rabbit Polyclonal Antibody

• Description: Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex.
• Product Name Alternative: 70 kDa ribosomal protein S6 kinase 1 antibody KS6B1_HUMAN antibody p70 alpha antibody P70 beta 1 antibody p70 ribosomal S6 kinase alpha antibody p70 ribosomal S6 kinase beta 1 antibody p70 S6 kinase alpha antibody P70 S6 Kinase antibody p70 S6 kinase, alpha 1 antibody p70 S6 kinase, alpha 2 antibody p70 S6K antibody p70 S6K-alpha antibody p70 S6KA antibody p70 (S6K) alpha antibody p70 (S6K)-alpha antibody p70-alpha antibody p70-S6K 1 antibody p70-S6K antibody P70S6K antibody P70S6K1 antibody p70S6Kb antibody PS6K antibody Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody Ribosomal protein S6 kinase beta 1 antibody Ribosomal protein S6 kinase beta-1 antibody Ribosomal protein S6 kinase I antibody RPS6KB1 antibody S6K antibody S6K-beta-1 antibody S6K1 antibody Serine/threonine kinase 14 alpha antibody Serine/threonine-protein kinase 14A antibody STK14A antibody
• Abbreviation: S6K-beta-2,S6K2,P70S6K2,p70-S6K 2,SRK,S6K-beta,p70 S6 kinase beta,p70 S6K-beta,p70 S6KB,p70-beta
• CAS Number: 9007-83-4
• Swiss Prot: P23443 Human, Q8BSK8 Mouse, P67999 Rat
• Cellular Locus: Cytoplasm, Nucleus
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within human p70 S6 Kinase beta aa 411-460.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: HeLa cell lysate, NIH/3T3 cell lysate, C6 cell lysate, HeLa, human pancreas tissue, HepG2.
• Concentration: 2 mg/mL
• Dilution: WB: 1:1,000 ;IF-Cell: 1:200 ;IHC-P: 1:5,000 ;FC: 1:100-1:200
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 59 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No