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Beta Catenin Rabbit Polyclonal Antibody

CAT: 0992-ER0805Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER0805Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Key downstream component of the canonical Wnt signaling pathway In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling.
CAS Number
9007-83-4
Product Name Alternative
β Catenin Beta catenin antibody Beta-catenin antibody Cadherin associated protein antibody Catenin (cadherin associated protein), beta 1, 88kDa antibody Catenin beta 1 antibody Catenin beta-1 antibody CATNB antibody CHBCAT antibody CTNB1_HUMAN antibody CTNNB antibody CTNNB1 antibody DKFZp686D02253 antibody FLJ25606 antibody FLJ37923 antibody OTTHUMP00000162082 antibody OTTHUMP00000165222 antibody OTTHUMP00000165223 antibody OTTHUMP00000209288 antibody OTTHUMP00000209289 antibody
Abbreviation
CTNB1
Swiss Prot
P35222 Human, Q02248 Mouse, Q9WU82 Rat
Cellular Locus
Cytoplasm, Nucleus, Cell junction, Cell membrane, Cytoskeleton, Synapse.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within C-terminal human Beta-Catenin.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC, IF-Cell, IF-Tissue
Positive Control
SW480 cell lysate, HT-29 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, Human brain tissue lysate, Mouse brain tissue lysate, Rat brain tissue lysate, HT-29, C6, human breast cancer tissue, human colon cancer tissue, mouse colon tissue, rat colon tissue.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:5,000 ;FC: 1:1,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:200-1:1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 85 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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