PKC beta Rabbit Polyclonal Antibody

PKC beta Rabbit Polyclonal Antibody

• Description: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.
• Product Name Alternative: KPCB_HUMAN antibody PKC beta antibody PKC-B antibody PKC-beta antibody PKCB antibody Prkcb antibody PRKCB I antibody PRKCB1 antibody PRKCB2 antibody Protein kinase C beta antibody Protein kinase C beta type antibody protein kinase C, beta 1 polypeptide antibody protein kinase C, beta-1 antibody
• Abbreviation: PKC-B, PRKCB, PKC-beta, PKCB, PRKCB1
• CAS Number: 9007-83-4
• Swiss Prot: P05771 Human, P68404 Mouse
• Cellular Locus: Cytoplasm, Nucleus, Membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Recombinant protein within human PKC beta aa 537-665.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: Rat spleen tissue lysate, Hela cell lysate, Hela, HepG2, human tonsil tissue, human spleen tissue, mouse spleen tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 77 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: No