Products for Research Use Only
RegisterLogin

PKC beta Rabbit Polyclonal Antibody

CAT: 0992-ER1802-14Size: 100 µLDry Ice: NoHazardous: No
Product image 1Product image 2Product image 3
1 / 3
CAT#:0992-ER1802-14Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.
CAS Number
9007-83-4
Product Name Alternative
KPCB_HUMAN antibody PKC beta antibody PKC-B antibody PKC-beta antibody PKCB antibody Prkcb antibody PRKCB I antibody PRKCB1 antibody PRKCB2 antibody Protein kinase C beta antibody Protein kinase C beta type antibody protein kinase C, beta 1 polypeptide antibody protein kinase C, beta-1 antibody
Abbreviation
PKC-B, PRKCB, PKC-beta, PKCB, PRKCB1
Swiss Prot
P05771 Human, P68404 Mouse
Cellular Locus
Cytoplasm, Nucleus, Membrane.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant protein within human PKC beta aa 537-665.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Rat spleen tissue lysate, Hela cell lysate, Hela, HepG2, human tonsil tissue, human spleen tissue, mouse spleen tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 77 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

Related Products

CatalogName
ET1609-44PKC beta 2 Recombinant Rabbit Monoclonal Antibody [ST48-06]
ET1705-30PKC beta 1 Recombinant Rabbit Monoclonal Antibody [JM43-26]
HA751582Phospho-PKC alpha/beta II (T638/T641) Recombinant Rabbit monoclonal Antibody
HA723825Phospho-PKC alpha/beta II (T638/T641) Recombinant Rabbit monoclonal Antibody
HA751595Phospho-PKC alpha/beta II (T638/T641) Recombinant Rabbit monoclonal Antibody
HA723796Phospho-PKC alpha/beta II (T638/T641) Recombinant Rabbit monoclonal Antibody
HA750325PKC delta Recombinant Rabbit monoclonal Antibody
HA751122PKC zeta Recombinant Rabbit monoclonal Antibody
HA500588Beta COP Rabbit polyclonal Antibody
R1706-13IKK beta Rabbit Polyclonal Antibody

Alternative Products

CatalogName
AP17400PU-NFSH beta (FSHB) (beta) Rabbit Polyclonal Antibody
GTR18106734-01GMF beta Rabbit Polyclonal Antibody
GTR18106512-01Beta-COP Rabbit Polyclonal Antibody
GTR18106470-01Beta-tubulin Rabbit Polyclonal Antibody
GTR18105767-01RhoGDI beta Rabbit Polyclonal Antibody
GTR18105330-01Beta-actin Rabbit Polyclonal Antibody
GTR18104956-01LT beta Rabbit Polyclonal Antibody
GTR18104864-01GSK3 beta Rabbit Polyclonal Antibody
GTR17763670-01Beta endorphin Rabbit Polyclonal Antibody
MBS8510472-01S100 beta Rabbit Polyclonal Antibody

Popular Products