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Flt3 Rabbit Polyclonal Antibody

CAT: 0992-ER2001-25Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER2001-25Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
CAS Number
9007-83-4
Product Name Alternative
CD 135 antibody CD135 antibody CD135 antigen antibody Fetal liver kinase 2 antibody FL cytokine receptor antibody Flk 2 antibody Flk2 antibody Flt 3 antibody FLT-3 antibody Flt3 antibody FLT3_HUMAN antibody FMS like tyrosine kinase 3 antibody Fms related tyrosine kinase 3 antibody Fms-like tyrosine kinase 3 antibody Growth factor receptor tyrosine kinase type III antibody Ly-72 antibody OTTHUMP0000004234 antibody Receptor type tyrosine protein kinase FLT3 antibody Stem cell tyrosine kinase 1 antibody Stk 1 antibody STK-1 antibody Stk1 antibody Tyrosine protein kinase receptor FLT3 antibody Tyrosine-protein kinase receptor FLT3 antibody
Abbreviation
FLT3
Swiss Prot
P36888 Human, Q00342 Mouse
Cellular Locus
Endoplasmic reticulum lumen, membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within mouse Flt3 aa 30-80.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC, IF-Cell
Positive Control
Rat testis lysates, 293T, rat testis tissue, human liver tissue, human spleen tissue, human placenta tissue, mouse brain tissue, THP-1.
Concentration
1 mg/mL
Dilution
WB:1:500-1:2,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100 ;IF-Cell:1:50
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 113 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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APRab11036-01Flt3 Rabbit Polyclonal Antibody

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