Flt3 Rabbit Polyclonal Antibody
CAT:
992-ER2001-25
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No


Flt3 Rabbit Polyclonal Antibody
- Description: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
- Product Name Alternative: CD 135 antibody CD135 antibody CD135 antigen antibody Fetal liver kinase 2 antibody FL cytokine receptor antibody Flk 2 antibody Flk2 antibody Flt 3 antibody FLT-3 antibody Flt3 antibody FLT3_HUMAN antibody FMS like tyrosine kinase 3 antibody Fms related tyrosine kinase 3 antibody Fms-like tyrosine kinase 3 antibody Growth factor receptor tyrosine kinase type III antibody Ly-72 antibody OTTHUMP0000004234 antibody Receptor type tyrosine protein kinase FLT3 antibody Stem cell tyrosine kinase 1 antibody Stk 1 antibody STK-1 antibody Stk1 antibody Tyrosine protein kinase receptor FLT3 antibody Tyrosine-protein kinase receptor FLT3 antibody
- Abbreviation: FLT3
- CAS Number: 9007-83-4
- Swiss Prot: P36888 Human, Q00342 Mouse
- Cellular Locus: Endoplasmic reticulum lumen, membrane.
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Synthetic peptide within mouse Flt3 aa 30-80.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IHC-P, FC, IF-Cell
- Positive Control: Rat testis lysates, 293T, rat testis tissue, human liver tissue, human spleen tissue, human placenta tissue, mouse brain tissue, THP-1.
- Concentration: 1 mg/mL
- Dilution: WB:1:500-1:2,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100 ;IF-Cell:1:50
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 113 kDa.
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
- Recombinant Antibody: No