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ERN1 Rabbit Polyclonal Antibody

CAT: 0992-ER1902-90Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1902-90Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity . The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA . The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes. Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A .
CAS Number
9007-83-4
Product Name Alternative
Endoplasmic reticulum (ER) to nucleus signalling 1 antibody Endoplasmic reticulum to nucleus signaling 1 antibody Endoplasmic reticulum-to-nucleus signaling 1 antibody Endoribonuclease antibody ER to nucleus signaling 1 antibody ERN 1 antibody Ern1 antibody ERN1_HUMAN antibody hIRE 1p antibody hIRE1p antibody Inositol requiring 1 antibody Inositol requiring 1, S. cerevisiae, homolog of antibody Inositol requiring enzyme 1, S. cerevisiae, homolog of antibody Inositol requiring protein 1 antibody inositol-requiring enzyme 1 antibody Inositol-requiring protein 1 antibody IRE 1 antibody IRE 1a antibody IRE 1P antibody Ire1 alpha antibody Ire1-alpha antibody IRE1a antibody Ire1alpha antibody IRE1P antibody MGC163277 antibody MGC163279 antibody Protein kinase/endoribonuclease antibody RGD1559716 antibody Serine/threonine protein kinase/endoribonuclease IRE1 antibody
Abbreviation
Serine/threonine-protein kinase/endoribonuclease IRE,Endoplasmic reticulum-to-nucleus signaling 1,Inositol-requiring protein 1,hIRE1p,Ire1-alpha,IRE1a,Serine/threonine-protein kinase,Endoribonuclease,ERN1
Swiss Prot
O75460 Human
Cellular Locus
Endoplasmic reticulum, Membrane.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within N-terminal Human ERN1.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P
Positive Control
C2C12 cell lysate, HepG2 cell lysate, rat uterus tissue, human appendix tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500 ;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size 110 kDa.
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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