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SynGAP Rabbit Polyclonal Antibody

CAT: 0992-ER1902-57Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1902-57Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded by the SYNGAP1 gene. SYNGAP1 is a ras GTPase-activating protein that is critical for the development of cognition and proper synapse function. Mutations in humans can cause intellectual disability or epilepsy. SynGAP1 is a complex protein with several functions that may be regulated temporally via complex isoforms. A well-documented function of SynGAP1 involves NMDA receptor-mediated synaptic plasticity and membrane insertion of AMPA receptors through the suppression of upstream signaling pathways. However, SynGAP1 has also been shown to function cooperatively with Unc51.1 in axon formation. One way SynGAP1 affects these processes is through the MAP kinase signaling pathway by attenuation of Ras signalling. However, alternative splicing and multiple translational start sites have been shown to cause opposing effects, illustrating the importance of multiple functional domains that reside within the c- and n-termini. For example, the expression of an α1 or α2 c-terminal variant of SynGAP1 will either increase or decrease synaptic strength, respectively. Overall, SynGAP1 is essential for development and survival, which is evident as knockout mice die perinatally.
CAS Number
9007-83-4
Product Name Alternative
DKFZp761G1421 antibody KIAA1938 antibody MRD5 antibody Neuronal RasGAP antibody OTTHUMP00000064825 antibody p135 SynGAP antibody Ras GTPase activating protein SynGAP antibody Ras GTPase-activating protein SynGAP antibody RASA 1 antibody RASA 5 antibody RASA1 antibody RASA5 antibody SYGP1_HUMAN antibody Synaptic Ras GAP 1 antibody Synaptic Ras GTPase activating protein 1 antibody Synaptic Ras GTPase activating protein 1 homolog antibody Synaptic Ras GTPase activating protein 135kDa antibody Synaptic Ras GTPase activating protein antibody Synaptic Ras GTPase-activating protein 1 antibody Synaptic Ras-GAP 1 antibody SYNGAP 1 antibody SYNGAP1 antibody
Abbreviation
Ras/Rap GTPase-activating protein SynGAP,Neuronal RasGAP,Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1,YNGAP1
Swiss Prot
Q96PV0 Human, Q9QUH6 Rat, F6SEU4 Mouse
Cellular Locus
Cytosol.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within human SynGAP aa 1100-1250.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
K562 cell lysate, mouse brain tissue lysate, human terus tissue, mouse brain tissue, SW620.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IHC-P: 1:50-1:100 ;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
148 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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