SynGAP Recombinant Rabbit Monoclonal Antibody [JE57-79]

• Description:

  SynGAP1 is a complex protein with several functions that may be regulated temporally via complex isoforms.[8] A well-documented function of SynGAP1 involves NMDA receptor-mediated synaptic plasticity and membrane insertion of AMPA receptors through the suppression of upstream signaling pathways. However, SynGAP1 has also been shown to function cooperatively with Unc51.1 in axon formation. One way SynGAP1 affects these processes is through the MAP kinase signaling pathway by attenuation of Ras signalling. However, alternative splicing and multiple translational start sites have been shown to cause opposing effects, illustrating the importance of multiple functional domains that reside within the c- and n-termini. For example, the expression of an α1 or α2 c-terminal variant of SynGAP1 will either increase or decrease synaptic strength, respectively. Overall, SynGAP1 is essential for development and survival, which is evident as knockout mice die perinatally.

• Product Name Alternative:

  DKFZp761G1421 antibody KIAA1938 antibody MRD5 antibody Neuronal RasGAP antibody OTTHUMP00000064825 antibody p135 SynGAP antibody Ras GTPase activating protein SynGAP antibody Ras GTPase-activating protein SynGAP antibody RASA 1 antibody RASA 5 antibody RASA1 antibody RASA5 antibody SYGP1_HUMAN antibody Synaptic Ras GAP 1 antibody Synaptic Ras GTPase activating protein 1 antibody Synaptic Ras GTPase activating protein 1 homolog antibody Synaptic Ras GTPase activating protein 135kDa antibody Synaptic Ras GTPase activating protein antibody Synaptic Ras GTPase-activating protein 1 antibody Synaptic Ras-GAP 1 antibody SYNGAP 1 antibody SYNGAP1 antibody

• Abbreviation:

  SYNGAP1

• Swiss Prot:

  F6SEU4 Mouse, Q9QUH6 Rat

• Cellular Locus:

  Cytosol, dendritic shaft, glutamatergic synapse, plasma membrane, postsynaptic density.

• Host:

  Rabbit

• Species Reactivity:

  Mouse, Rat

• Immunogen:

  Synthetic peptide within Human SynGAP aa 1,294-1,343 / 1,343.

• Isotype:

  IgG

• Clone:

  JE57-79

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Rabbit monoclonal Antibody

• Applications:

  WB, IHC-P, IF-Tissue

• Positive Control:

  Mouse brain tissue lysate, mouse hippocampus tissue lysate, rat brain tissue lysate, rat hippocampus tissue lysate, mouse brain tissue, mouse hippocampus tissue, rat brain tissue, rat hippocampus tissue.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:2,000 ;IHC-P: 1:500-1:2,000 ;IF-Tissue: 1:1,000

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 148 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3