Connexin-26 Rabbit Polyclonal Antibody

Connexin-26 Rabbit Polyclonal Antibody

• Description: Gap junction beta-2 protein (GJB2), also known as connexin 26 (Cx26) — is a protein that in humans is encoded by the GJB2 gene. Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The connexins are designated by their molecular mass. Another system of nomenclature divides gap junction proteins into two categories, alpha and beta, according to sequence similarities at the nucleotide and amino acid levels. For example, CX43 (GJA1) is designated alpha-1 gap junction protein, whereas GJB1 (CX32), and GJB2 (CX26; this protein) are called beta-1 and beta-2 gap junction proteins, respectively. This nomenclature emphasizes that GJB1 and GJB2 are more homologous to each other than either of them is to gap junction protein, alpha GJA1. Connexin 26 also plays a role in tumor suppression through mediation of the cell cycle. The abnormal expression of Cx26, correlated with several types of human cancers, may serve as a prognostic factor for cancers such as colorectal cancer, breast cancer, and bladder cancer. Furthermore, Cx26 over-expression is suggested to promote cancer development by facilitating cell migration and invasion and by stimulating the self-perpetuation ability of cancer stem cells.
• Product Name Alternative: connexin 26 antibody Connexin-26 antibody Cx26 antibody CXB2_HUMAN antibody DFNA3 antibody DFNB1 antibody Gap junction beta-2 protein antibody GJB2 antibody HID antibody KID antibody NSRD1 antibody PPK antibody
• Abbreviation: Gjb2
• CAS Number: 9007-83-4
• Swiss Prot: P29033 Human, Q00977 Mouse, P21994 Rat
• Cellular Locus: Cell membrane, gap junction.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within rat Connexin-26 aa 90-130.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P, FC
• Positive Control: Human skin tissue lysates, rat testis tissue, human liver tissue, mouse colon tissue, A431.
• Concentration: 1 mg/mL
• Dilution: WB:1:500-1:1,000 ;IHC-P:1:50-1:200 ;FC:1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 26 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No