Connexin 45 / GJA7 / Cx45 Rabbit Polyclonal Antibody

Connexin 45 / GJA7 / Cx45 Rabbit Polyclonal Antibody

• Description: Gap junction gamma-1 protein (GJC1), also known as gap junction alpha-7 protein (GJA7) and connexin 45 (Cx45) — is a protein that in humans is encoded by the GJC1 gene. Cx45 is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. GJs consist of 3 major connexin (Cx) isoforms—Cx43, Cx40, and Cx45—each of which are characterized by chamber-specific regional distribution and permeation properties. Cx45 is strongly expressed in the early embryonic myocardium and is required for cardiac development (1). Homozygous Cx45-deficient mice are embryonic lethal; however, in the adult heart, Cx45 is expressed mainly at the SA and AV nodes and is not essential for survival of adult mice. Disease-causing mutations in GJ gamma-1 protein (GJC1), which encodes Cx45, have not yet been identified.
• Product Name Alternative: Connexin 45 / GJA7 antibody Connexin 45 antibody Connexin-45 antibody Connexin45 antibody CX 31.9 antibody CX 45 antibody CX31.9 antibody Cx45 antibody CXG1_HUMAN antibody DKFZp686P0738 antibody Gap junction alpha 7 protein antibody Gap junction alpha-7 protein antibody Gap junction gamma 1 protein antibody Gap junction gamma-1 protein antibody Gap junction protein alpha 7 45kDa antibody Gap junction protein alpha 7 antibody Gap junction protein, gamma 1, 45kDa antibody GJA 7 antibody GJA7 antibody GJC1 antibody GJD3 antibody
• Abbreviation: Cx45, GJC1, GJA7
• CAS Number: 9007-83-4
• Swiss Prot: P36383 Human, P28229 Mouse, A4GG66 Rat
• Cellular Locus: Cell membrane, Gap junction.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human Connexin 45 aa 257-396 / 396.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: SH-SY5Y, A431, rat uterus tissue, human liver cancer tissue, human kidney tissue, human placenta tissue.
• Concentration: 1 mg/mL
• Dilution: WB:1:500-1:1000 ;IF-Cell:1:500-1:100 ;IHC-P:1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 45 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No