GSDMC Rabbit Polyclonal Antibody

• Description:

  This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering cell death. Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. The functional mechanisms and physiological proteases that cleave and activate this pore-forming protein are unknown.

• Product Name Alternative:

  Gasdermin C antibody Gasdermin-C antibody GSDMC antibody GSDMC_HUMAN antibody Melanoma derived leucine zipper, extra nuclear factor antibody Melanoma-derived leucine zipper-containing extranuclear factor antibody MLZE antibody

• Abbreviation:

  GSDMC

• Swiss Prot:

  Q9BYG8 Human

• Cellular Locus:

  Cell membrane, Cytoplasm, Membrane.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Recombinant protein within Human GSDMC aa 1-220 / 508.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IHC-P

• Positive Control:

  Human stomach tissue lysates, human lung tissue, human kidney tissue, A549.

• Concentration:

  1 mg/mL

• Dilution:

  WB:1:1,000-1:2,000 ;IHC-P:1:50-1:200

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 58 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4