P2X7 Rabbit Polyclonal Antibody
CAT:
992-ER1901-50
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
P2X7 Rabbit Polyclonal Antibody
- Description: P2X purinoceptor 7 is a protein that in humans is encoded by the P2RX7 gene. The product of this gene belongs to the family of purinoceptors for ATP. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay criteria. The receptor is found in the central and peripheral nervous systems, in microglia, in macrophages, in uterine endometrium, and in the retina. The P2X7 receptor also serves as a pattern recognition receptor for extracellular ATP-mediated apoptotic cell death, regulation of receptor trafficking, mast cell degranulation, and inflammation. P2X7 receptors respond to BzATP more readily than ATP. ADP and AMP are weak agonists of P2X7 receptors, but a brief exposure to ATP can increase their effectiveness. Glutathione has been proposed to act as a P2X7 receptor agonist when present at milimolar levels, inducing calcium transients and GABA release from retinal cells. The P2X7 receptor current can be blocked by zinc, calcium, magnesium, and copper.
- Product Name Alternative: ATP receptor antibody P2rx7 antibody P2RX7_HUMAN antibody P2X purinoceptor 7 antibody P2X7 antibody P2Z receptor antibody Purinergic receptor antibody purinergic receptor P2X, ligand gated ion channel, 7 antibody
- Abbreviation: P2rx7
- CAS Number: 9007-83-4
- Swiss Prot: Q99572 Human, Q9Z1M0 Mouse, Q64663 Rat
- Cellular Locus: Cell membrane.
- Host: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Immunogen: Synthetic peptide within mouse P2X7 aa 100-200.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IF-Cell, IHC-P, FC
- Positive Control: Rat brain tissue lysates, EA.hy926, MCF-7, rat cerebellum tissue, human kidney tissue, mouse brain tissue, mouse kidney tissue, THP-1.
- Concentration: 1 mg/mL
- Dilution: WB:1:200-1:500;IF-Cell:1:50-1:100;IHC-P:1:50-1:200;FC:1:50-1:100
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 69 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
- Recombinant Antibody: No