Syntrophin alpha 1 Rabbit Polyclonal Antibody

• Description:

  Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.

• Product Name Alternative:

  59 kDa dystrophin-associated protein A1 acidic component 1 antibody Alpha-1-syntrophin antibody Pro-TGF-alpha cytoplasmic domain-interacting protein 1 antibody SNT1 antibody SNT2 antibody SNT3 antibody Snta1 antibody SNTA1_HUMAN antibody SNTB1 antibody SNTB2 antibody Syntrophin alpha 1 antibody Syntrophin beta 1 antibody Syntrophin beta 2 antibody Syntrophin-1 antibody TACIP1 antibody

• Abbreviation:

  SNTA1

• Swiss Prot:

  Q13424 Human, Q61234 Mouse,

• Cellular Locus:

  Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane.

• Host:

  Rabbit

• Species Reactivity:

  Mouse, Rat, Human

• Immunogen:

  Synthetic peptide within mouse Syntrophin alpha 1 aa 174-223 / 503.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB

• Positive Control:

  Mouse skeletal muscle tissue lysate, mouse heart tissue lysate, rat skeletal muscle tissue lysate, rat heart tissue lysate, rat eyeball tissue lysate.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500-1:2,000

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 54 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4