GSK3 alpha Rabbit Polyclonal Antibody
CAT:
992-R1312-1
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
GSK3 alpha Rabbit Polyclonal Antibody
- Description: Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene. It acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. GSK3 alpha requires primed phosphorylation of the majority of its substrates. It contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. GSK3 alpha regulates glycogen metabolism in liver, but not in muscle. It may also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, GSK3 alpha regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin.
- Product Name Alternative: DKFZp686D0638 antibody Glycogen synthase kinase 3 alpha antibody Glycogen synthase kinase-3 alpha antibody GSK 3 alpha antibody GSK 3A antibody GSK-3 alpha antibody Gsk3a antibody GSK3A_HUMAN antibody GSK3alpha antibody Serine/threonine protein kinase GSK3A antibody
- Abbreviation: GSK-3 alpha
- CAS Number: 9007-83-4
- Swiss Prot: P49840 Human
- Cellular Locus: Cytoplasm, Nucleus, Apical dendrite, Mitochondrion.
- Host: Rabbit
- Species Reactivity: Human
- Immunogen: Synthetic peptide within Human GSK3 alpha aa 434-483 / 483.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IF-Cell, IHC-P, FC
- Positive Control: Hela, HepG2, PC-3M, Jurkat, human brain
- Concentration: 1 mg/mL
- Dilution: WB: 1:1000 ;IF-Cell: 1:100
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: Predicted band size: 51 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Recombinant Antibody: No