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GSK3 alpha Rabbit Polyclonal Antibody

CAT: 0992-R1312-1Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1312-1Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene. It acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. GSK3 alpha requires primed phosphorylation of the majority of its substrates. It contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. GSK3 alpha regulates glycogen metabolism in liver, but not in muscle. It may also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, GSK3 alpha regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin.
CAS Number
9007-83-4
Product Name Alternative
DKFZp686D0638 antibody Glycogen synthase kinase 3 alpha antibody Glycogen synthase kinase-3 alpha antibody GSK 3 alpha antibody GSK 3A antibody GSK-3 alpha antibody Gsk3a antibody GSK3A_HUMAN antibody GSK3alpha antibody Serine/threonine protein kinase GSK3A antibody
Abbreviation
GSK-3 alpha
Swiss Prot
P49840 Human
Cellular Locus
Cytoplasm, Nucleus, Apical dendrite, Mitochondrion.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide within Human GSK3 alpha aa 434-483 / 483.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
Hela, HepG2, PC-3M, Jurkat, human brain
Concentration
1 mg/mL
Dilution
WB: 1:1000 ;IF-Cell: 1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 51 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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