KV1.1 Rabbit Polyclonal Antibody

KV1.1 Rabbit Polyclonal Antibody

• Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation of delayed rectifier potassium channels. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Regulates neuronal excitability in hippocampus, especially in mossy fibers and medial perforant path axons, preventing neuronal hyperexcitability. Response to toxins that are selective for KCNA1, respectively for KCNA2, suggests that heteromeric potassium channels composed of both KCNA1 and KCNA2 play a role in pacemaking and regulate the output of deep cerebellar nuclear neurons.
• Product Name Alternative: AEMK antibody EA1 antibody Episodic ataxia with myokymia antibody HBK1 antibody HUK1 antibody Kca1 1 antibody Kcna1 antibody KCNA1_HUMAN antibody Kcpvd antibody KV1.1 antibody MBK1 antibody mceph antibody MGC124402 antibody MGC126782 antibody MGC138385 antibody MK1 antibody MK1, mouse, homolog of KV1.1 antibody Potassium channel protein 1 antibody Potassium voltage gated channel shaker related subfamily member 1 antibody Potassium voltage gated channel subfamily A member 1 antibody Potassium voltage gated channel, shaker related subfamily, member 1 (episodic ataxia with myokymia) antibody Potassium voltage-gated channel subfamily A member 1 antibody RBK1 antibody RCK1 antibody Shak antibody Shaker related subfamily member 1 antibody Voltage gated potassium channel subunit Kv1.1 antibody Voltage-gated K (+) channel HuKI antibody Voltage-gated potassium channel HBK1 antibody Voltage-gated potassium channel subunit Kv1.1 antibody
• Abbreviation: Kcna1
• CAS Number: 9007-83-4
• Swiss Prot: Q09470 Human, P16388 Mouse, P10499 Rat
• Cellular Locus: Endoplasmic reticulum. Plasma membrane. Other locations.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within mouse KV11 aa 175-224 / 495.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IHC-P, FC
• Positive Control: Rat brain tissue lysate, rat spinal cord tissue, mouse brain tissue, A549.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 56 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No