TdT Rabbit Polyclonal Antibody

TdT Rabbit Polyclonal Antibody

• Description: Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase expressed in immature lymphocytes of the thymus and bone marrow, as well as certain leukemic cells. The nuclear enzyme TdT plays a critical role in generating immune receptor diversity. During rearrangement of Ig and TCR V region genes, TdT catalyzes the addition of N nucleotides without a DNA template to V-D and D-J junctions in both Ig and TCR as well as the V-J junctions in the TCR (1–3). During the fetal and newborn period, TdT activity is absent, resulting in an N region-deficient Ag receptor repertoire significantly lacking in the diversity observed in the junctional regions of Igs and TCRs of adult animals
• Alternative Name: Deoxynucleotidyltransferase terminal antibody DNA nucleotidylexotransferase antibody DNTT antibody Nucleosidetriphosphate DNA deoxynucleotidylexotransferase antibody TDT antibody TDT_HUMAN antibody Terminal addition enzyme antibody Terminal deoxynucleotidyltransferase antibody Terminal deoxyribonucleotidyltransferase antibody Terminal transferase antibody
• Abbreviation: Terminal transferase
• Swiss Prot: P04053 Human
• Cellular Locus: Cell nucleus
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human TdT aa 25-74 / 509.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB
• Positive Control: Jurkat
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1,000
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 58kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No