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TdT Rabbit Polyclonal Antibody

CAT: 0992-0807-9Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-0807-9Size:100 µL
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Description
Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase expressed in immature lymphocytes of the thymus and bone marrow, as well as certain leukemic cells. The nuclear enzyme TdT plays a critical role in generating immune receptor diversity. During rearrangement of Ig and TCR V region genes, TdT catalyzes the addition of N nucleotides without a DNA template to V-D and D-J junctions in both Ig and TCR as well as the V-J junctions in the TCR (1–3). During the fetal and newborn period, TdT activity is absent, resulting in an N region-deficient Ag receptor repertoire significantly lacking in the diversity observed in the junctional regions of Igs and TCRs of adult animals
CAS Number
9007-83-4
Product Name Alternative
Deoxynucleotidyltransferase terminal antibody DNA nucleotidylexotransferase antibody DNTT antibody Nucleosidetriphosphate DNA deoxynucleotidylexotransferase antibody TDT antibody TDT_HUMAN antibody Terminal addition enzyme antibody Terminal deoxynucleotidyltransferase antibody Terminal deoxyribonucleotidyltransferase antibody Terminal transferase antibody
Abbreviation
Terminal transferase
Swiss Prot
P04053 Human
Cellular Locus
Cell nucleus
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide within Human TdT aa 25-74 / 509.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
Jurkat
Concentration
1 mg/mL
Dilution
WB: 1:500-1,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
58kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No