BOB1 Rabbit Polyclonal Antibody

• Description :

  Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Reduced activation of Bob1-deficient B cells following antigenic stimulation is often reported. The action of Bob1 on B cell maturation and tolerance could be mediated by effects on B cell activation, in part by regulating the expression of immunosuppressive miRNAs. Bob1 has long been considered a B cell‐specific factor that interacts with the transcription factors Oct1 and Oct2 to enhance octamer‐dependent transcription. Bob1 can directly bind to and transactivate the promoters of Bcl6 and Btla.

• CAS Number :

  9007-83-4

• Product Name Alternative :

  B cell Oct binding protein 1 antibody B cell specific coactivator OBF 1 antibody B cell specific coactivator OBF1 antibody B-cell-specific coactivator OBF-1 antibody BOB 1 antibody BOB-1 antibody OBF 1 antibody OBF1 antibody OBF1_HUMAN antibody OCA B antibody OCA-B antibody OCAB antibody OCT binding factor 1 antibody OCT-binding factor 1 antibody POU class 2 associating factor 1 antibody POU domain class 2 associating factor 1 antibody POU domain class 2-associating factor 1 antibody Pou2af1 antibody

• Abbreviation :

  POU domain class 2-associating factor 1, B-cell-specific coactivator OBF-1, BOB-1, OCA-B, OCT-binding factor 1, POU2AF1, OBF1

• Swiss Prot :

  Q16633 Human, Q64693 Mouse,

• Cellular Locus :

  Nucleus.

• Host :

  Rabbit

• Species Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant protein within Human BOB1 aa 10-180.

• Isotype :

  IgG

• Conjugation :

  Non-conjugated

• Type :

  Rabbit polyclonal Antibody

• Applications :

  WB, FC

• Positive Control :

  Daudi.

• Concentration :

  1 mg/mL

• Dilution :

  WB:1:500;FC:1:50-1:100

• Purity :

  Immunogen affinity purified.

• Form :

  Liquid

• Buffer :

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight :

  35 kDa (predicted molecular weight: 27 kDa)

• Storage Conditions :

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody :

  No