BOB1 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-97Size: 100 µLDry Ice: NoHazardous: No
CAT#:0992-ER1803-97Size:100 µL
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Description
Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Reduced activation of Bob1-deficient B cells following antigenic stimulation is often reported. The action of Bob1 on B cell maturation and tolerance could be mediated by effects on B cell activation, in part by regulating the expression of immunosuppressive miRNAs. Bob1 has long been considered a B cell‐specific factor that interacts with the transcription factors Oct1 and Oct2 to enhance octamer‐dependent transcription. Bob1 can directly bind to and transactivate the promoters of Bcl6 and Btla.
CAS Number
9007-83-4
Product Name Alternative
B cell Oct binding protein 1 antibody B cell specific coactivator OBF 1 antibody B cell specific coactivator OBF1 antibody B-cell-specific coactivator OBF-1 antibody BOB 1 antibody BOB-1 antibody OBF 1 antibody OBF1 antibody OBF1_HUMAN antibody OCA B antibody OCA-B antibody OCAB antibody OCT binding factor 1 antibody OCT-binding factor 1 antibody POU class 2 associating factor 1 antibody POU domain class 2 associating factor 1 antibody POU domain class 2-associating factor 1 antibody Pou2af1 antibody
Abbreviation
POU domain class 2-associating factor 1, B-cell-specific coactivator OBF-1, BOB-1, OCA-B, OCT-binding factor 1, POU2AF1, OBF1
Swiss Prot
Q16633 Human, Q64693 Mouse,
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human BOB1 aa 10-180.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, FC
Positive Control
Daudi.
Concentration
1 mg/mL
Dilution
WB:1:500;FC:1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
35 kDa (predicted molecular weight: 27 kDa)
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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