Integrin linked ILK Rabbit Polyclonal Antibody

Integrins are heterodimers composed of non-covalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind to ligands that are components of the extracellular matrix. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. ILK (integrin-linked kinase) was identified as a serine/threonine kinase that phosphorylates b1 and b3 integrins. ILK expression has been shown to be reduced in response to Fibronectin, a known integrin ligand. Overexpression of ILK was shown to upregulate the Fibronectin matrix assembly in epithelial cells, indicating a potential role for ILK in cell growth, cell survival and tumorigenesis.

9007-83-4

59 kDa serine/threonine protein kinase antibody 59 kDa serine/threonine-protein kinase antibody DKFZp686F1765 antibody Epididymis secretory protein Li 28 antibody HEL S 28 antibody ILK 1 antibody ILK 2 antibody ILK antibody ILK-1 antibody ILK-2 antibody ILK_HUMAN antibody ILK1 antibody ILK2 antibody Integrin linked kinase 2 antibody Integrin linked Kinase antibody Integrin linked protein kinase antibody Integrin-linked protein kinase antibody p59 antibody p59ILK antibody

ILK1, ILK2, ILK

Q13418 Human, O55222 Mouse, Q99J82 Rat

Cell junction, Cell membrane, Cytoplasm.

Recombinant protein within Human Integrin linked ILK aa 1-290.

Non-conjugated

Rabbit polyclonal Antibody

WB, IF-Cell, IHC-P

Mouse skeletal muscle tissue, rat lung tissue, A431, NIH/3T3, rat skeletal muscle tissue, human kidney tissue, human pancreas tissue, mouse heart tissue.

1 mg/mL

WB:1:500 ;IF-Cell:1:50-1:200 ;IHC-P:1:50-1:200

Immunogen affinity purified.

Liquid

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

51 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.