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Rad21 Rabbit Polyclonal Antibody

CAT: 0992-ER1803-73Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-73Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
CAS Number
9007-83-4
Product Name Alternative
CDLS4 antibody Double-strand-break repair protein rad21 homolog antibody hHR21 antibody HR21 antibody HRAD21 antibody KIAA0078 antibody MCD1 antibody Nuclear matrix protein 1 antibody NXP-1 antibody NXP1 antibody Protein involved in DNA double-strand break repair antibody RAD21 antibody RAD21 homolog (S. pombe) antibody RAD21 homolog antibody RAD21_HUMAN antibody Scc1 antibody SCC1 homolog antibody
Abbreviation
hHR21, NXP-1, RAD21, HR21, KIAA0078, NXP1, SCC1
Swiss Prot
O60216 Human, Q61550 Mouse,
Cellular Locus
Centromere, Chromosome, Nucleus, Cytoplasm, Cytoskeleton.
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within Human Rad21 aa 252-456 / 631.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Mouse ovary tissue lysate, Daudi cell lysate, MG-63, SiHa, SK-Br-3, rat brain tissue, human thyroid gland carcinoma tissue, human colon tissue, mouse testis tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:100-1:400
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 72 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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