MCU Rabbit Polyclonal Antibody

• Description:

  Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex. Activity is regulated by MICU1 and MICU2. At low Ca2+ levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca2+ levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells.

• Product Name Alternative:

  C109A_HUMAN antibody C10orf42 antibody Calcium uniporter protein mitochondrial antibody Ccdc109a antibody Coiled-coil domain-containing protein 109A antibody HsMCU antibody Mitochondrial Calcium Uniporter antibody

• Abbreviation:

  HsMCU, MCU, C10orf42, CCDC109A

• Swiss Prot:

  Q8NE86 Human, Q3UMR5 Mouse

• Cellular Locus:

  Mitochondrion.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein within Human MCU aa 51-225 / 351.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, IHC-P, IF-Cell, FC

• Positive Control:

  A549 cell lysate, HL-60 cell lysate, mouse spleen tissue lysates, mouse brain tissue lysates, HT-29, rat brain tissue, human colon tissue, mouse testis tissue, A549.

• Concentration:

  1 mg/mL

• Dilution:

  WB: 1:500-1:1,000 ;IHC-P: 1:50-1:200 ;IF-Cell: 1:50 ;FC: 1:1,000

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 40 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4