PKM2 Rabbit Polyclonal Antibody

In mammals, four different isoenzymes exist for pyruvate kinase. Pyruvate kinases are responsible for catalyzing the final step in glycolysis: the conversion of phosphoenolpyruvate to pyruvate with the coinciding generation of ATP. The PKM (pyruvate kinase, muscle) gene encodes the M1- and M2-type isoenzymes through alternative splicing events. Both M1- and M2-type isoforms exists as tetramers and are stimulated by fructose 1,6-bisphosphate. In addition, both isoforms exhibit thyroid hormone binding activity and may be referred to as CTHBP (cytosolic thyroid hormone-binding protein) or THBP1. The M2-type isoform also interacts with Oct-4 via its C-terminal domain, functioning to enhance Oct-4 transcriptional activity. Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.

9007-83-4

CTHBP antibody Cytosolic thyroid hormone binding protein antibody Cytosolic thyroid hormone-binding protein antibody KPYM_HUMAN antibody MGC3932 antibody OIP 3 antibody OIP-3 antibody OIP3 antibody OPA interacting protein 3 antibody Opa-interacting protein 3 antibody p58 antibody PK muscle type antibody PK, muscle type antibody PK2 antibody PK3 antibody PKM antibody PKM2 antibody pykm antibody Pyruvate kinase 2/3 antibody Pyruvate kinase 3 antibody Pyruvate kinase isozymes M1/M2 antibody Pyruvate kinase muscle antibody Pyruvate kinase muscle isozyme antibody pyruvate kinase PKM antibody Pyruvate kinase, muscle 2 antibody TCB antibody THBP1 antibody Thyroid hormone binding protein 1 antibody Thyroid hormone binding protein cytosolic antibody Thyroid hormone-binding protein 1 antibody Tumor M2 PK antibody Tumor M2-PK antibody

CTHBP, OIP-3, THBP1, PKM, OIP3, PK2, PK3, PKM2

P14618 Human

Cytoplasm. Nucleus.

Synthetic peptide within human PKM2 aa 370-450.

Non-conjugated

Rabbit polyclonal Antibody

WB, IF-Cell, IHC-P

Wild-type MDA-MB-231 whole cell lysate, SiHa cell lysate, A549 cell lysate, PC-3 cell lysate, A549, F9, PC-3M, human tonsil tissue, human thyroid carcinoma tissue, human colon cancer tissue, human breast cancer tissue.

1 mg/mL

WB: 1:500-1:1,000 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:50-1:400

Immunogen affinity purified.

Liquid

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Predicted band size: 58 kDa

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.