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DIAPH3 Rabbit Polyclonal Antibody

CAT: 0992-ER1802-54Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1802-54Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DIAPH3 (diaphanous homolog 3), also known as DIAP3, DRF3 or mDia2 of mouse origin, is a 1,193 amino acid member of the formin homology protein family and is required for the correct function of various cellular processes. DIAPH3 binds to both Profilin, a protein involved in cell maintenance, and to the GTP-bound form of Rho (Rho-GTP). Binding to both of these proteins allows DIAPH3 to recruit Profilin to the membrane, in a Rho-dependent manner. At the membrane, DIAPH3 promotes Actin polymerization and is required for stress fiber formation, cytokinesis and transcriptional activation of the serum response factor (SRF). DIAPH3 also regulates Actin dynamics by coupling Src tyrosine kinase (c-Src) and Rho during Actin signaling events. DIAPH3 contains one diaph-anous autoregulatory domain (DAD) and one Rho GTPase-binding domain (GBD). When DAD and GBD are intramolecularly bound, the GBD is occupied and DIAPH3 is inactive. Interruption of the DAD-GBD bond allows the GBD to bind to Rho-GTP, thus activating DIAPH3. Seven isoforms of DIAPH3 exist due to alternative splicing events.
CAS Number
9007-83-4
Product Name Alternative
AN antibody AUNA1 antibody Dia2 antibody diap3 antibody DIAP3_HUMAN antibody DIAPH3 antibody Diaphanous homolog 3 (Drosophila) antibody Diaphanous homolog 3 antibody Diaphanous related formin 3 antibody Diaphanous, Drosophila, homolog of, 3 antibody Diaphanous-related formin-3 antibody DKFZp434C0931 antibody DKFZp686A13178 antibody DRF3 antibody FLJ34705 antibody mDia2 antibody NSDAN antibody OTTHUMP00000018480 antibody Protein diaphanous homolog 3 antibody RP11-26P21.1 antibody
Abbreviation
DRF3, DIAPH3, DIAP3
Swiss Prot
Q9NSV4 Human, Q9Z207 Mouse
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide within Human DIAPH3 aa 1,059-1,108 / 1,193.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P, FC
Positive Control
A431, LOVO, SiHa, human kidney tissue, human placenta tissue.
Concentration
1 mg/mL
Dilution
IF-Cell: 1:50-1:200;IHC-P: 1:50-1:400;FC: 1:50-1:100;WB: 1:500
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 137/80 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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